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KMID : 0361019980410091169
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Korean Journal of Otolaryngology - Head and Neck Surgery
1998 Volume.41 No. 9 p.1169 ~ p.1173
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Expression of Matrix-Metalloproteinase-2, Urokinase - Type Plasminogen Activator Inhibitor-1 in Invasion Mode and Lymph Node Metastasis of Laryngeal Squamous Cell Carcinoma
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Abstract
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Backgrounds and Objectives: Metastatic process of cells involves dissolution of tumor matrix and enetraion of the basement membrane (BM) which involves the active proteolysis of type Ⅳ collagen, proteoglycanm laminin, and flbronectin. The
hallmark of invasion is the penetration of epithelial BM by serine protease and matrix metalloproteinase. Matrix metalloproteinases (MMP) include type Ⅳ collagenase, interstitial collagenase, and stromelysin, where MMP-2 and MMP-9 and considered
to be
the most important in tumor invasion. Urokinase-type plasminogen activator(u-PA) promotes conversion of plasminogen to active plasminogen causing degradation of fibrin, fibronectin, proteoglycan, and laminin. Plasminogen activator inhibitor
(PAI-1)
is a
specific inhibitor of u-PA, and it is involved in defense from tumor invasion through metastasis. In this thesis, the expression patterns of MMP-2, u-PA and PAI-1 were investigated in laryngeal squamous cell carcinoma in tumor invasion and lymph
node
metastasis. Materials and Methods: Tumor tissue from 50 cases of laryngeal cancer paraffin block specimuns were used from the archives of Department of Pathology in Korea University hospital to study the expression pattern of MMP-2, u-PA,
and
PAI-1. Results: The results have shown that in laryngeal cancer, the positive expression rate for MMP-2 was 54%, u-PA 72%, and PAI-1 46%. The expression of MMP-2 was related with lymph node metastasis, and u-PA expression increased
according
to
the increase of primary tumor staging. There were no significant relationship between the expression rates of MMP-2, u-PA, and PAI-1 with histopathologic grading and invasion mode. There results suggest that u-PA could be used as a biological
marker for
tumor size and MMP-2 for lymph node metastasis, whereas PAI-1 is not a significant marker for tumor invasion or lymph node metastasis.
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KEYWORD
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